Xilcef Syrup
Cefadroxil
250mg
Deurali Janta Pharmaceuticals Pvt. Ltd.
| Pack size | 30ml |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 60.00 NPR |
Available as:
Indications
Xilcef Syrup is used for:
Pharyngitis, Susceptible infections, Sore throat, Tonsillitis, Urinary tract infection, Reproductive tract infection and skin infections
Adult Dose
Oral
Tonsillitis; Skin and skin structure infections; Streptococcal pharyngitis; Urinary tract infections
Adult: 1-2 g daily as a single or in 2 divided doses.
Hepatic impairment: No dosage adjustment needed.
Child Dose
Oral
Tonsillitis; Skin and skin structure infections; Streptococcal pharyngitis; Urinary tract infections
Child: >6 yr <40 kg: 30-50 mg/kg daily as a single or in 2 divided doses, up to 100 mg/kg daily.
Renal Dose
Renal impairment:
CrCl (ml/min)
26-50 0.5-1 g bid.
11-25 0.5-1 g once daily.
<10 0.5-1 g every 36 hr.
Administration
May be taken with or without food. May be taken w/ meals to reduce GI discomfort.
Contra Indications
Hypersensitivity to cephalosporins.
Precautions
Impaired renal function; pregnancy and lactation.
Lactation: enters breast milk; use with caution
Pregnancy-Lactation
Interactions
Concomitant use w/ bacteriostatic antibiotics (e.g. tetracycline, erythromycin, sulfonamides, chloramphenicol) may cause antagonistic effect. May potentiate nephrotoxic effects of aminoglycoside antibiotics, polymyxin B, colistin or high-dose loop diuretics. May enhance the anticoagulant effect of vit K antagonists. May diminish the therapeutic effect of BCG, typhoid vaccine and Na picosulfate. May attenuate the effect of oral contraceptives. Increased serum concentration w/ probenecid. Reduced bioavailability w/ colestyramine.
Adverse Effects
Side effects of Cefadroxil :
1-10%
Diarrhea
<1%
Abdominal pain,Dyspepsia,Nausea,Vomiting,Rash,Urticaria,Pseudomembranous colitis,Stevens-Johnson syndrome,Anaphylaxis,Transaminases increased,Neutropenia
Potentially Fatal: Anaphylactic reaction; pseudomembranous colitis.
Mechanism of Action
Cefadroxil binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. Cefadroxil is not active against Proteus, Pseudomonas, Enterobacter, Morganella, Serratia and Listeria monocytogenes.
Note
Xilcef 250mg Syrup manufactured by Deurali Janta Pharmaceuticals Pvt. Ltd.. Its generic name is Cefadroxil. Xilcef is availble in Nepal.
Farmaco Nepal drug index information on Xilcef Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.