Xone 2 Injection
Ceftriaxone
2gm
Alkem Laboratories Ltd.
| Pack size | 1 |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 203.68 NPR |
Available as:
Indications
Xone 2 Injection is used for:
Pneumonia, Meningitis, Acute otitis media, Lyme disease, Typhoid fever, Otitis media, Pelvic inflammatory disease, Septicemia, Skin and Skin-Structure Infections, Gonorrhea, Respiratory tract infections, Urinary tract infections, Bone and Joint Infections, Chlamydia infection, Surgical Prophylaxis
Adult Dose
Susceptible infections IV/IM 1-2 g/day, up to 4 g/day for severe infections.
Intra-abdominal Infections
Complicated, mild-to-moderate, community acquired: 1-2 g/day IV in single daily dose or divided q12hr for 4-7 days, in combination with metronidazole
Meningitis
2 g IV q12hr for 7-14 days
Acute Uncomplicated Pyelonephritis
1-2 g IV qDay
Typhoid fever
2 g IV once daily for 14 days.
Surgical Prophylaxis
Prophylaxis of surgical infection
1 g IV 0.5-2 hours before procedure
Uncomplicated Gonococcal Infections
Uncomplicated gonococcal infection of pharynx, cervix, urethra, or rectum: ceftriaxone 250 mg IM once plus azithromycin 1 g PO once (preferred) or alternatively, doxycycline 100 mg PO q12hr for 7 days
Pelvic Inflammatory Disease
250 mg IM as single dose with doxycycline, with or without metonidazole for 14 days
Child Dose
Children: IV, IM: 50–75 mg/kg/day, max 2 g/day q24h
50 mg/kg, max 1 g, 1–3 doses IM for AOM q24h
100 mg/kg/day for meningitis, max 4 g/day q12h
Renal Dose
Renal impairment:
CrCl (ml/min)
<10 Max: 2 g daily.
Administration
IV/IM Administration
IV: Infuse intermittently over 30 minutes
IM: Inject deep into large muscle mass
Contra Indications
Hypersensitivity to cephalosporins; hyperbilirubinaemic neonates. Do not use calcium or calcium-containing solutions or products with or within 48 hr of ceftriaxone administration due to risk of calcium-ceftriaxone precipitate formation.
Precautions
History of penicillin allergy; severe renal impairment; pregnancy and lactation; superinfection.
Lactation: Drug enters breast milk in low concentrations; use with caution
Pregnancy-Lactation
Interactions
May increase nephrotoxicity of aminoglycosides. May diminish therapeutic effect of BCG, typhoid vaccine, Na picosulfate. May increase anticoagulant effect of vit K antagonists (e.g. warfarin). May increase serum level w/ probenecid.
Potentially Fatal: Admin w/ Ca-containing IV soln may cause precipitation of a crystalline material in the lungs and kidneys.
Adverse Effects
Side effects of Ceftriaxone :
>10%
Induration after IM injection (5-17%)
1-10%
Eosinophilia (6%),Thrombocytosis (5%),Diarrhea (3%),Elevated hepatic transaminases (3%),Leukopenia (2%),Rash (2%),Increased blood urea nitrogen (BUN) (1%),Induration at IV site (1%),Pain (1%)
<1%
Agranulocytosis,Anaphylaxis,Anemia,Basophilia,Bronchospasm,Candidiasis,Chills,Diaphoresis,Dizziness,Dysgeusia,Flushing,Gallstones,Glycosuria,Headache,Hematuria,Hemolytic anemia,Increased alkaline phosphatase or bilirubin,Increased creatinine,Jaundice,Leukocytosis,Lymphocytosis,Lymphopenia,Monocytosis,Nausea,Neutropenia,Phlebitis,Prolonged or decreased prothrombin time (PT),Pruritus,Renal stones,Serum sickness,Thrombocytopenia,Urinary casts,Vaginitis,Vomiting
Mechanism of Action
Ceftriaxone binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Note
Xone 2 2gm Injection manufactured by Alkem Laboratories Ltd.. Its generic name is Ceftriaxone. Xone 2 is availble in Nepal.
Farmaco Nepal drug index information on Xone 2 Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.