Zantor 80 Tablet

Febuxostat
80mg
Quest Pharmaceuticals Pvt. Ltd.
Pack size 1
Dispensing mode
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Agent
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Indications

Zantor 80 Tablet is used for: Gout, Hyperuricemia

Adult Dose

Chronic Gout 40 mg/day PO initially; maintenance: 40-80 mg/day; increased if serum uric acid is >6 mg/mL after 2 weeks Hepatic impairment Mild to moderate (Child-Pugh class A or B): Dosage adjustment not necessary Severe (Child-Pugh class C): Data not available; use with caution

Child Dose

Safety and efficacy not established

Renal Dose

Renal impairment Mild to moderate (CrCl 30-89 mL/min): Dosage adjustment not necessary Severe (CrCl <30 mL/min): Data not available; use with caution

Administration

May be taken with or without food. May be taken w/o regard to antacid use.

Contra Indications

Patients being treated with azathioprine, mercaptopurine, or theophylline.

Precautions

Gout Flare: An increase in gout flares is frequently observed during initiation of anti-hyperuricemic agents, including Febustat. If a gout flare occurs during treatment, Febustat need not be discontinued. Prophylactic therapy (i.e., non-steroidal anti-inflammatory drug (NSAID) or colchicine upon initiation of treatment) may be beneficial for up to six months. Lactation: Unknown whether drug is excreted into breast milk; use with caution

Pregnancy-Lactation

Interactions

May increase plasma conc of mercaptopurine, azathioprine. Alteration of metabolism of xanthine oxidase substrate drugs (eg theophylline).

Adverse Effects

Side effects of Febuxostat : >1% Arthralgia,Elevated liver function test (LFT) results,Liver function abnormalities,Nausea,Rash

Mechanism of Action

Febuxostat selectively inhibits xanthine oxidase, the enzyme that catalyses the conversion of hypoxanthine to xanthine to uric acid, thereby decreasing serum concentrations of uric acid.

Note

Zantor 80 80mg Tablet manufactured by Quest Pharmaceuticals Pvt. Ltd.. Its generic name is Febuxostat. Zantor 80 is availble in Nepal. Farmaco Nepal drug index information on Zantor 80 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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