Zantor 80 Tablet
Febuxostat
80mg
Quest Pharmaceuticals Pvt. Ltd.
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Available as:
Indications
Zantor 80 Tablet is used for:
Gout, Hyperuricemia
Adult Dose
Chronic Gout
40 mg/day PO initially; maintenance: 40-80 mg/day; increased if serum uric acid is >6 mg/mL after 2 weeks
Hepatic impairment
Mild to moderate (Child-Pugh class A or B): Dosage adjustment not necessary
Severe (Child-Pugh class C): Data not available; use with caution
Child Dose
Safety and efficacy not established
Renal Dose
Renal impairment
Mild to moderate (CrCl 30-89 mL/min): Dosage adjustment not necessary
Severe (CrCl <30 mL/min): Data not available; use with caution
Administration
May be taken with or without food. May be taken w/o regard to antacid use.
Contra Indications
Patients being treated with azathioprine, mercaptopurine, or theophylline.
Precautions
Gout Flare: An increase in gout flares is frequently observed during initiation of anti-hyperuricemic agents, including Febustat. If a gout flare occurs during treatment, Febustat need not be discontinued. Prophylactic therapy (i.e., non-steroidal anti-inflammatory drug (NSAID) or colchicine upon initiation of treatment) may be beneficial for up to six months.
Lactation: Unknown whether drug is excreted into breast milk; use with caution
Pregnancy-Lactation
Interactions
May increase plasma conc of mercaptopurine, azathioprine. Alteration of metabolism of xanthine oxidase substrate drugs (eg theophylline).
Adverse Effects
Side effects of Febuxostat :
>1%
Arthralgia,Elevated liver function test (LFT) results,Liver function abnormalities,Nausea,Rash
Mechanism of Action
Febuxostat selectively inhibits xanthine oxidase, the enzyme that catalyses the conversion of hypoxanthine to xanthine to uric acid, thereby decreasing serum concentrations of uric acid.
Note
Zantor 80 80mg Tablet manufactured by Quest Pharmaceuticals Pvt. Ltd.. Its generic name is Febuxostat. Zantor 80 is availble in Nepal.
Farmaco Nepal drug index information on Zantor 80 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.