Zestimox Tablet
Moxifloxacin 0.5% Eye prep
0.5% w/v/ml
DCI Pharmaceuticals Pvt. Ltd.
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Indications
Zestimox Tablet is used for:
Bacterial Conjunctivitis
Adult Dose
Ophthalmic
Bacterial conjunctivitis
Adult: As 0.5% soln: Instill 1 drop into the affected eye(s) tid for 7 days.
Child Dose
Ophthalmic
Bacterial conjunctivitis
Child: >1 yr: Instill 1 drop into the affected eye(s) tid for 7 days.
Renal Dose
Administration
Contra Indications
Patients with a history of hypersensitivity to Moxifloxacin, to other Quinolones or to any of the components in this medication
Precautions
As with other anti-infectives, prolonged use may result in overgrowth of non-susceptible organisms, including fungi. If superinfection occurs, discontinue use and institute alternative therapy. To prevent contamination do not touch the tip of the dropper to eye, eyelid or any surface of of the affected eye. Keep the bottle tightly closed after use.
Lactation: Unknown whether drug is excreted in breast milk; use with caution
Pregnancy-Lactation
Interactions
Additive effect on QT interval prolongation w/ other drugs that prolong QT interval (e.g. erythromycin, TCAs, antipsychotic agents). Decreased absorption and bioavailability w/ Al- or Mg-containing antacids, or Fe or Zn preparations. Concomitant use of corticosteroids increases the risk of severe tendon disorders esp in elderly (>60 yr). Decreased absorption w/ sucralfate or didanosine.
Potentially Fatal: Concurrent use of class Ia (e.g. quinidine, procainamide) or III (e.g. amiodarone, sotalol) antiarrhythmic drugs or w/ other drugs that prolong QT interval (e.g. erythromycin, TCAs, antipsychotic agents) may cause additive effect on QT interval prolongation.
Adverse Effects
Side effects of Moxifloxacin 0.5% Eye prep :
1-10%
Conjunctivitis,Dry eye,Fever,Increased cough,Infection,Ocular discomfort,Ocular hyperemia,Ocular pain,Ocular pruritus,Otitis media.Pharyngitis,Rash,Rhinitis,Subconjunctival hemorrhage.Tearing
Mechanism of Action
Moxifloxacin inhibits the topoisomerase II (DNA gyrase) and topoisomerase IV required for bacterial DNA replication, transcription, repair and recombination.
Note
Zestimox 0.5% w/v/ml Tablet manufactured by DCI Pharmaceuticals Pvt. Ltd.. Its generic name is Moxifloxacin 0.5% Eye prep. Zestimox is availble in Nepal.
Farmaco Nepal drug index information on Zestimox Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.