Zydotum 1.5 G Injection
Ceftazidime + Sulbactam
Venus
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| Retail Price | 588.79 NPR |
Indications
Zydotum 1.5 G Injection is used for:
Indicated for the treatment of patients with infections caused by susceptible strains of the designated organisms in the following disease :
Bone and joint infections
Urinary tract infections in adult and geriatric population
Lower respiratory tract infections in paediatric patients including pneumonia caused by resistant Pseudomonas
Adult Dose
Parenteral
Adult: 1-2 g 8-12 hrly as deep IM inj, slow IV inj over 3-5 min or IV infusion for up to 30 min.
Child Dose
Parenteral
Child: <40 kg: 100-150 mg/kg daily in 3 divided doses. Max: 6 g daily.
Renal Dose
Renal impairment: Loading dose: 1 g. Maintenance doses based on CrCl. May need to increase dose by 50% in severe infections. Peritoneal dialysis: Loading dose is followed by 500 mg 24 hrly; may add ceftazidime to the dialysis fluid (usually 125-250 mg for 2 L of dialysis fluid). Haemodialysis: Admin loading dose then 1 g after each dialysis period.
CrCl (ml/min) Dosage Recommendation
<5 500 mg 48 hrly.
6-15 500 mg 24 hrly.
16-30 1 g 24 hrly.
31-50 1 g 12 hrly.
Administration
Contra Indications
Hypersensitivity to ceftazidime or other cephalosporins.
Precautions
Patient w/ history of penicillin allergy, seizure disorder. Renal impairment. Pregnancy and lactation. Monitoring Parameters Monitor renal function. Observe for signs and symptoms of anaphylaxis during 1st dose.
Pregnancy-Lactation
Interactions
May increase nephrotoxicity of aminoglycosides. May diminish therapeutic effect of BCG, typhoid vaccine, Na picosulfate. May increase anticoagulant effect of vit K antagonists (e.g. warfarin). May increase serum level w/ probenecid.
Adverse Effects
Side effects of Ceftazidime + Sulbactam :
Diarrhoea, nausea, vomiting, abdominal pain, metallic taste; eosinophilia, thrombocytosis; pruritus, rash (maculopapular, erythematous), urticaria, photosensitivity, angioedema, fever; transient increases in serum concentrations of AST, ALT, alkaline phosphatase, LDH, γ-glutamyltransferase, bilirubin, serum creatinine concentrations; local reactions (e.g. phlebitis, pain or inflammation at inj site), candidiasis, vaginitis. Rarely, transient leucopenia, neutropenia thrombocytopenia, agranulocytosis, lymphocytosis.
Potentially Fatal: Anaphylactic reactions, Clostridium difficile-associated diarrhoea and colitis.
Mechanism of Action
Ceftazidime binds to 1 or more of the penicillin-binding proteins (PBPs) which inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Note
Zydotum 1.5 G Injection manufactured by Venus. Its generic name is Ceftazidime + Sulbactam. Zydotum 1.5 G is availble in Nepal.
Farmaco Nepal drug index information on Zydotum 1.5 G Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.