Acetaminophen (paracetamol) + Chlorpheniramine
Indications
Acetaminophen (paracetamol) + Chlorpheniramine is used for:
Relief of Cold & Flu Symptoms
Adult Dose
Relief of Cold & Flu Symptoms
2 tablets PO q4hr
Child Dose
Relief of Cold & Flu Symptoms
>12 years: 2 tablets PO q4hr
Renal Dose
Administration
Contra Indications
Contraindicated in documented hypersensitivity; asthma attacks, narrow-angle glaucoma, symptomatic prostate hypertrophy, bladder-neck obstruction, and stenosing peptic ulcer; known G-6-PD deficiency
Chlorpheniramine may cause significant confusional symptoms; not for administration to premature or full-term neonates
Acetaminophen hepatotoxicity possible in chronic alcoholics following various dose levels; severe or recurrent pain or high or continued fever may indicate a serious illness; contained in many OTC products and combined use with these products may result in toxicity due to cumulative doses exceeding recommended maximum dose
Acetaminophen: Risk for rare, but serious skin reactions that can be fatal; these reactions include Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP); symptoms may include skin redness, blisters and rash
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Acetaminophen (paracetamol) + Chlorpheniramine :
Hypotension
Palpitations
Tachycardia
Anxiety
Confusion
Depression
Dizziness
Drowsiness
Euphoria
Fatigue
Headache
Insomnia
Irritability
Nervousness
Tremors
Anorexia
Constipation
Diarrhea
Nausea
Vomiting
Agranulocytosis
Anemia
Blood dyscrasias (neutropenia, pancytopenia, leukopenia, thrombocytopenia)
Hemolytic anemia
Bilirubin and alkaline phosphatase may increase
Thickening of bronchial secretions
Wheezing
Dry mouth, nose, throat
Mechanism of Action
Chlorpheniramine blocks muscle responses in histamine and acts as an antagonism of the constrictor effects of histamine on respiratory smooth muscle.
Acetaminophen blocks pain impulse generation peripherally and may inhibit the generation of prostaglandin in the CNS. Reduces fever by inhibiting the hypothalamic heat-regulating center.