Alpha Lipoic Acid + Mecobalamin (Methylcobalamin)
Indications
Alpha Lipoic Acid + Mecobalamin (Methylcobalamin) is used for:
Peripheral neuropathies, Diabetic neuropathy
Adult Dose
Oral
Peripheral neuropathies, Diabetic neuropathy
Adult: 1 capsule daily in 2-3 divided doses.
Child Dose
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Precautions
Alpha-lipoic acid can lower blood sugar levels, so people with diabetes or low blood sugar should take alpha-lipoic acid only under the supervision of their health care provider.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Alpha Lipoic Acid + Mecobalamin (Methylcobalamin) :
Anorexia, nausea, vomiting and diarrhoea. Insomnia, fatigue and skin rash.
Allergic skin conditions are among the few reported adverse reactions of LA administration in humans.
Mechanism of Action
Alpha-lipoic acid is an antioxidant made by the body. It is found in every cell, where it helps turn glucose into energy. Antioxidants attack "free radicals," waste products created when the body turns food into energy. Free radicals cause harmful chemical reactions that can damage cells, making it harder for the body to fight off infections. They also damage organs and tissues.
Other antioxidants work only in water (such as vitamin C) or fatty tissues (such as vitamin E). But alpha-lipoic acid is both fat and water soluble. That means it can work throughout the body. Antioxidants in the body are used up as they attack free radicals. But evidence suggests alpha-lipoic acid may help regenerate these other antioxidants and make them active again.
In the cells of the body, alpha-lipoic acid is changed into dihydrolipoic acid. Alpha-lipoic acid is not the same as alpha linolenic acid, which is an omega-3 fatty acid that may help heart health. There is confusion between alpha-lipoic acid and alpa linolenic acid because both are sometimes abbreviated ALA. Alpha-lipoic acid is also sometimes called lipoic acid.
Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.