Aluminium Hydroxide + Magnesium Trisilicate

Indications

Aluminium Hydroxide + Magnesium Trisilicate is used for: Heartburn, Indigestion, Gastric Hyperacidity, Peptic ulcer disease, Gastroesophageal reflux disorder (GERD)

Adult Dose

Chew 2 to 4 tablets after meals and at bedtime as needed (up to 4 times a day). Do not take more than 16 tablets in 24 hours

Child Dose

<12 years: Not recommended

Renal Dose

Administration

After meals and at bedtime as needed. For best results, drink a half glass of water or other liquid after each dose.

Contra Indications

Hypophosphataemia.

Precautions

Renal dysfunction, low phosphate diet, prolonged use. Lactation: Unknown whether distributed in breast milk

Pregnancy-Lactation

Interactions

Aluminium Hydroxide: Enhanced absorption with citrates or ascorbic acid. Decreases absorption of allopurinol, tetracyclines, quinolones, cephalosporins, biphosphonate derivatives, corticosteroids, cyclosporin, delavirdine, Fe salts, imidazole antifungals, isoniazid, mycophenolate, penicillamine, phosphate supplements, phenytoin, phenothiazines, trientine. Magnesium Trisilicate: None well documented.

Adverse Effects

Side effects of Aluminium Hydroxide + Magnesium Trisilicate : >10% Aluminum,Chalky taste,Constipation,Fecal impaction,Stomach cramps 1-10% Aluminum Nausea,Vomiting,Aluminum intoxication,Hypophosphatemia,Osteomalacia,Magnesium,Diarrhea,Hypermagnesemia

Mechanism of Action

Aluminum hydroxide: Neutralizes stomach hydrocloride to form AlCl3 salt plus water; increases gastric pH. Magnesium Trisilicate neutralizes gastric acidity by increasing gastric pH