Ambroxol + Salbutamol
Indications
Ambroxol + Salbutamol is used for:
Productive cough w/ difficulty in breathing.
Adult Dose
Oral
Adult: 5-10 mL 3-4 times a day.
Child Dose
Oral
Children >2 years: 5 mL 3-4 times a day.
Not recommended for children <2 years.
Renal Dose
Administration
Contra Indications
Hypersensitivity. Hyperthyroidism. CV disease eg ischaemic heart disease, arrhythmia or tachycardia. Pregnancy & lactation. Childn <1 yr.
Precautions
Do not take for persistent cough. Childn <2 yr.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Ambroxol + Salbutamol :
GI disturbances, headache, dry mouth & skin rashes. Tremor, nervous tension, peripheral vasodilatation, palpitation, tachycardia.
Mechanism of Action
Ambroxol is an active N-desmethyl metabolite of the mucolytic bromhexine. Although its mechanism of action has not been fully defined, it may increase the quantity and decrease the viscosity of tracheobronchial secretions. It may also act as an expectorant, increasing mucociliary transport via stimulation of ciliary motility.
Salbutamol acts by stimulating β2-adrenergic receptors in the lungs to relax bronchial smooth muscle, thereby relieving bronchospasm associated with bronchial asthma, emphysema and chronic bronchitis. Because of this action, salbutamol increases vital capacity, decreases residual volume and reduces airway resistance.