Amlodipine + Metoprolol
Indications
Amlodipine + Metoprolol is used for:
Hypertension
Adult Dose
Oral
Adult
Tablet (5/50mg)
1 tab once a day
Child Dose
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity
It should be avoided in patients with a history of asthma or lung disease.
Precautions
The medicine may not be safe to use during pregnancy or breastfeeding.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Amlodipine + Metoprolol :
Common
Headache
Ankle swelling
Flushing (sense of warmth in the face, ears, neck and trunk)
Slow heart rate
Tiredness
Stomach pain
Nausea
Edema (swelling)
Constipation
Palpitations
Cold extremities
Mechanism of Action
Amlodipine, a dihydropyridine Ca-channel blocker, reduces peripheral vascular resistance and BP by relaxing coronary vascular smooth muscle and coronary vasodilation through inhibition of Ca ion transmembrane influx into cardiac and vascular smooth muscles.
Metoprolol selectively inhibits β1-adrenergic receptors but has little or no effect on β2-receptors except in high doses. It does not exhibit membrane stabilising or intrinsic sympathomimetic activity.