Amoxicillin + + Dicloxacilin

Indications

Amoxicillin + + Dicloxacilin is used for: Susceptible infections

Adult Dose

Oral Susceptible infections Adult: Per capsule contains amoxicillin 250 mg and dicloxacillin 250 mg: 2-4 caps tid.

Child Dose

Renal Dose

Administration

Contra Indications

Hypersensitivity to penicillins.

Precautions

Allergy to cephalosporins, infectious mononucleosis, neonates with jaundice, H/o convulsions, lactation.

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Amoxicillin + + Dicloxacilin : GI upsets, rash, urticaria, neutropenia, neurotoxicity, agranulocytosis (rarely), increased incidence of phlebitis with IV use. Potentially Fatal: Rarely anaphylactic shock; pseudomembranous colitis.

Mechanism of Action

Amoxicillin is bactericidal against non β-lactamase producing gm+ve organisms and selected gm-ve pathogens. Dicloxacillin is a beta-lactamase resistant penicillin active against gm+ve organisms including beta-lactamase (penicillinase) producing strains of Staphylococci. It is highly active against Staph aureus, Strep pyogenes, Strep viridans and Strep pneumoniae. Also effective against penicillinase producing gonococci and against N meningitidis and H influenzae.