Anthralin

Indications

Anthralin is used for: Psoriasis

Adult Dose

Psoriasis 1% cream: Rub cream qDay well into psoriatic lesions in skin until absorbed; avoid applying excessive quantity 0.5% scalp cream: Apply as directed after washing hair and remove by washing or showering

Child Dose

Renal Dose

Administration

Contra Indications

Hypersensitivity Acute or actively inflamed psoriatic eruptions

Precautions

Avoid contact with eyes or mucous membranes If redness observed reduce frequency of application or discontinue therapy May stain fingernails, hair, or fabrics Use with caution in patients with extensive and prolonged applications Lactation: Excretion in milk unknown/not recommended

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Anthralin : Allergic reactions around surrounding uninvolved skin Temporary discoloration of skin Lesion soreness Staining of hair, skin, and fingernails

Mechanism of Action

Not fully understood Inhibits cell proliferation putatively through inhibition of DNA synthesis as well as from its strong reducing properties Anti-psoriatic action may be partly through inactivating epidermal 12-lipoxygenase & reducing levels of endothelial cell adhesion molecules which are markedly elevated in psoriasis