Atropine Sulphate 1%

Indications

Atropine Sulphate 1% is used for: Keratitis, iritis, cyclitis, & refractive procedure in children. Mydriatic & cyclopplegic.

Adult Dose

Ophthalmic Inflammatory eye disorders Adult: Instill 1-2 drops of a 1% solution up to 4 times daily. Ointment: as required. Eye refraction Adult: Instill 1 drop of a 1% solution bid for 1-2 days before the procedure, or on a single occasion 1 hr before the procedure.

Child Dose

Ophthalmic Inflammatory eye disorders Child: As sulfate: Instill 1 drop of a 1% solution up to tid. Ointment: as required. Eye refraction Child: As sulfate: Instill 1 or 2 drops of a 0.5% soln (or 1 drop of a 1% solution) bid for 1-3 days before the procedure, with a further dose given 1 hr before the procedure.

Renal Dose

Administration

Contra Indications

Narrow angle glaucoma.

Precautions

Toxic systemic reaction may occur in the very young & very old. Lactation: Trace amounts enter breast milk; use with caution (AAP Committee states "compatible with nursing")

Pregnancy-Lactation

Interactions

Additive anticholinergic effects with quinidine, antidepressants and some antihistamines.

Adverse Effects

Side effects of Atropine Sulphate 1% : Eye drops: Systemic toxicity esp in children, on prolonged use may lead to irritation, hyperaemia, oedema, dry eyes, vascular congestion, dermatitis, blurred vision and conjunctivitis. Increased intraocular pressure.

Mechanism of Action

Atropine is an anticholinergic agent which competitively blocks the muscarinic receptors in peripheral tissues. It also has mydriatic and cycloplegic effect.