Atropine Sulphate 1%
Indications
Atropine Sulphate 1% is used for:
Keratitis, iritis, cyclitis, & refractive procedure in children. Mydriatic & cyclopplegic.
Adult Dose
Ophthalmic
Inflammatory eye disorders
Adult: Instill 1-2 drops of a 1% solution up to 4 times daily.
Ointment: as required.
Eye refraction
Adult: Instill 1 drop of a 1% solution bid for 1-2 days before the procedure, or on a single occasion 1 hr before the procedure.
Child Dose
Ophthalmic
Inflammatory eye disorders
Child: As sulfate: Instill 1 drop of a 1% solution up to tid.
Ointment: as required.
Eye refraction
Child: As sulfate: Instill 1 or 2 drops of a 0.5% soln (or 1 drop of a 1% solution) bid for 1-3 days before the procedure, with a further dose given 1 hr before the procedure.
Renal Dose
Administration
Contra Indications
Narrow angle glaucoma.
Precautions
Toxic systemic reaction may occur in the very young & very old.
Lactation: Trace amounts enter breast milk; use with caution (AAP Committee states "compatible with nursing")
Pregnancy-Lactation
Interactions
Additive anticholinergic effects with quinidine, antidepressants and some antihistamines.
Adverse Effects
Side effects of Atropine Sulphate 1% :
Eye drops: Systemic toxicity esp in children, on prolonged use may lead to irritation, hyperaemia, oedema, dry eyes, vascular congestion, dermatitis, blurred vision and conjunctivitis. Increased intraocular pressure.
Mechanism of Action
Atropine is an anticholinergic agent which competitively blocks the muscarinic receptors in peripheral tissues. It also has mydriatic and cycloplegic effect.