Azithromycin 1% Eye drop
Indications
Azithromycin 1% Eye drop is used for:
Bacterial Conjunctivitis, Neonatal Conjunctivitis, Blepharitis
Adult Dose
Bacterial conjunctivitis
Adult: Instill 1 drop in the affected eye(s) bid for 2 days, then once daily for the next 5 days.
Child Dose
Bacterial conjunctivitis
Child >1 year: Instill 1 drop in the affected eye(s) bid for 2 days, then once daily for the next 5 days.
Renal Dose
Administration
Contra Indications
Known hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic. Coadministration w/ pimozide. History of cholestatic jaundice/hepatic dysfunction associated w/ prior use of azithromycin.
Precautions
Anaphylaxis and hypersensitivity have been reported with systemic use of azithromycin . Growth of resistant organisms may occur with prolonged use. patients should not wear contact lenses if they have signs or symptoms of bacterial conjunctivitis.
Lactation: Excretion in milk unknown; use with caution
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Azithromycin 1% Eye drop :
1-10%
Eye irritation (1-2%)
<1%
Anaphylaxis,Contact dermatitis,Corneal erosion,Dry eye,Rash,Urticaria,Dygeusia,Nasal congestion,Ocular discharge,Punctate keratitis,Sinusitis
Mechanism of Action
Azithromycin is a semisynthetic azalide antibiotic. It blocks transpeptidation by binding to 50s ribosomal subunit of susceptible organisms and disrupting RNA-dependent protein synthesis at the chain elongation step.