Betamethasone 0.1% + Neomycin Sulphate 0.5% E/E prep
Indications
Betamethasone 0.1% + Neomycin Sulphate 0.5% E/E prep is used for:
Allergic and inflammatory conditions of the eye & ear, otitis externa, uveitis, marginal keratitis, allergic conjunctivitis, blepharitis and episcleritis
Adult Dose
Eye, Ear & Nasal Drops: Eye: 1 drop instilled into the eye every one or two hours until control is achieved, when the frequency may be reduced.
Ear: 2 or 3 drops instilled into the ear, every two or three hours until control is achieved, when the frequency can be reduced.
Nose: 2 or 3 drops instilled into each nostril two or three times daily.
Eye Ointment: It should be applied thinly and evenly to the conjunctival sac at night (If eye drops used during day) or 3-4 times daily (if ointment used alone).
Child Dose
Renal Dose
Administration
Eye Ointment: Apply ¼ inch long to the lower eye lid 2-3 times daily and/or at night.
Contra Indications
Skin lesions of viral, fungal or bacterial origin, acne rosacea and perioral dermatitis.
Precautions
Avoid prolonged continuous treatment especially in infants and children. Extended treatment may increase the risk of contact sensitisation and development of antibiotic resistance. Not to be used for >7 days if there is no clinical improvement. Increased risk of glaucoma if preparation enters the eye(s). Pregnancy and lactation.
Pregnancy-Lactation
Interactions
If there is significant systemic absorption, neomycin sulfate may increase the respiratory depressant effects of neuromuscular blockers.
Adverse Effects
Side effects of Betamethasone 0.1% + Neomycin Sulphate 0.5% E/E prep :
Prolonged intensive treatment may cause local atrophic changes in the skin e.g. striae, thining and dilatation of superficial blood vessels. Dryness, itching, irritation, hypopigmentation, burning sensation at the site of application or miliaria.
Mechanism of Action
Betamethasone valerate is a corticosteroid which is effective in inflammatory dermatoses. It is also effective in less responsive conditions such as psoriasis. Neomycin sulfate is a broad spectrum antibiotic. It is bactericidal against many bacteria which are commonly associated with skin infections.