Betamethasone + Clioquinol (Iodochlorhydroxyquin) + Gentamicin + Tolnaftate Topical

Indications

Betamethasone + Clioquinol (Iodochlorhydroxyquin) + Gentamicin + Tolnaftate Topical is used for: Management of dermatoses complicated by bacterial & fungal infection.

Adult Dose

Topical Apply a thin layer to affected areas tid-qid.

Child Dose

Renal Dose

Administration

Contra Indications

Hypersensitivity to any of the ingredients. Rosacea, acne, peri-oral dermatitis, tuberculosis of the skin and varicose ulcers. Skin lesions caused by infections with viruses (e.g. herpes simplex, vaccinia or varicella).

Precautions

For external use only. Do not use in or around the eye. Not recommended during prenancy & breast feeding.

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Betamethasone + Clioquinol (Iodochlorhydroxyquin) + Gentamicin + Tolnaftate Topical : Prolonged and intensive treatment may cause local atrophic changes in the skin such as stria, thinning, loss of elasticity, dilatation of the superficial blood vessels, telangiectasia and ecchymosis. Prolonged use, use of large amounts, treatment of extensive areas, or application to damaged skin, when is used and when the occlusive dressing technique is applied can result in sufficient systemic absorption to produce the features of hypercortisonism such as depression of the hypothalamic-pituitaryadrenal axis with consequent suppression of the adrenal gland. These effects are most likely to be severe in infants and children. Growth may be retarded and a Cushingoid state may be produced.

Mechanism of Action

Betamethasone controls the rate of protein synthesis, depresses the migration of polymorphonuclear leukocytes and fibroblasts, and reverses capillary permeability and lysosomal stabilization at the cellular level to prevent or control inflammation. Tolnaftate exact mode of action is not known, but the drug has been demonstrated to distort the hyphae and stunt mycelial growth in susceptible fungi. Gentamicin binds to 30s and 50s ribosomal subunits of susceptible bacteria disrupting protein synthesis, thus rendering the bacterial cell membrane defective. Clioquinol is a halogenated hydroxyquinoline with antibacterial and antifungal activity.