Bismuth subsalicylate
Indications
Bismuth subsalicylate is used for:
Diarrhea, nausea, heartburn, indigestion, and upset stomach.
Adult Dose
Adult: 30 ml 3-4 times daily 30 mintues before meal.
Child Dose
Child: 3-12 years: 5-15 ml
<3 years: Safety and efficacy not established
Renal Dose
Administration
Drink plenty of clear fluids to prevent dehydration caused by diarrhea
Do not use for >2 days
Contra Indications
Hypersensitivity to bismuth, aspirin, other salicylates.
Infectious diarrhea, high fever, von Willebrand disease, hemorrhage, ulcer or GI bleeding with black or bloody stool, hemophilia.
In pediatric patients, chicken pox or influenza (risk of Reye syndrome); changes in behavior with nausea and vomiting may be early sign of Reye syndrome.
Precautions
May cause black tongue and/or black stool.
Pregnancy-Lactation
Pregnancy category: C; D in 3rd trimester
Interactions
Adverse Effects
Side effects of Bismuth subsalicylate :
>10%
Nausea (12%)
1-10%
Diarrhea (7%),Abdominal pain (7%),Melena (3%),Upper respiratory tract infection (2%),Constipation (2%),Anorexia (2%),Vomiting (2%),Asthenia (2%),Discolored tongue (2%),Headache (2%),Dyspepsia (2%),Dizziness (2%),Stool abnormality (1%),Duodenal ulcer (1%),Sinusitis (1%),Taste perversion (1%),Flatulence (1%),GI hemorrhage (1%),Pain (1%),Insomnia (1%),Anal discomfort (1%),Paresthesia (1%)
Frequency Not Defined
Anxiety,Confusion,Depression,Tinnitus,Weakness,Gray-black stool,Impaction,Muscle spasm,Neurotoxicity (rare)
Mechanism of Action
Antimicrobial anti-inflammatory action (bismuth); antisecretory effect (salicylate).