Calcipotriene 0.005%
Indications
Calcipotriene 0.005% is used for:
Plaque psoriasis, Scalp psoriasis
Adult Dose
Apply a thin layer of ointment once or twice daily.
Child Dose
Renal Dose
Administration
Rub in gently and completely.
May use for up to 8 weeks
Contra Indications
Patients with a history of hypersensitivity to any of the components of the preparation. It should not be used by patients with demonstrated hypercalcemia or evidence of vitamin D toxicity.
Precautions
For external use only. Keep out of the reach of children. Always wash hands thoroughly after use.
Transient, rapidly reversible elevation of serum calcium has occurred with use . If elevation in serum calcium outside the normal range should occur, discontinue treatment until normal calcium levels are restored.
Lactation: excretion in milk unknown; use with caution
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Calcipotriene 0.005% :
>10%
Burning,Itching,Skin irritation
1-10%
Dermatitis,Dry skin,Erythema,Peeling,Worsening of psoriasis including facial/scalp,Rash
<1%
Folliculitis,Hypercalcemia,Hyperpigmentation,Skin atrophy
Mechanism of Action
In vitro evidence suggests drug is roughly equipotent to natural vitamin D in its effects on proliferation & differentiation of various cell types.