Chloramphenicol 5% + Lidocaine Hydrochloride 1% Ear drops

Indications

Chloramphenicol 5% + Lidocaine Hydrochloride 1% Ear drops is used for: Acute bacterial ear infections

Adult Dose

Otic/Aural Otitis externa Adult: Instill 2-3 drops into the ear bid-tid.

Child Dose

Renal Dose

Administration

Contra Indications

History of hypersensitivity or toxic reaction to the drug; Perforated ear drum. Herpes simplex and other virul conditions of the eye or ear, mycosis.

Precautions

Avoid prolonged use. Discontinue immediately if local hypersensitivity reactions occur.

Pregnancy-Lactation

Interactions

Decreased effects of iron and vitamin B12 in anaemic patients. Phenobarbitone and rifampin reduce efficacy of chloramphenicol. Impairs the action of oral contraceptives. Potentially Fatal: Increases the effect of oral anticoagulants, oral hypoglycaemic agents, phenytoin. Avoid concomitant administration with drugs that depress bone marrow function. May increase serum levels w/ cimetidine and propranolol. Increased risk of cardiac depression w/ ?-blockers and other antiarrhythmics. Additive cardiac effects w/ IV phenytoin. Hypokalaemia caused by acetazolamide, loop diuretics and thiazides may antagonise effect of lidocaine. Dose requirements may be increased w/ long-term use of phenytoin and other enzyme-inducers.

Adverse Effects

Side effects of Chloramphenicol 5% + Lidocaine Hydrochloride 1% Ear drops : Ear drops: Ototoxicity.

Mechanism of Action

Chloramphenicol inhibits bacterial protein synthesis by binding to 50s subunit of the bacterial ribosome, thus preventing peptide bond formation by peptidyl transferase. It has both bacteriostatic and bactericidal action against H. influenzae, N. meningitidis and S. pneumoniae. Lidocaine is an amide type local anaesth. It stabilises the neuronal membrane and inhibits Na ion movements, which are necessary for conduction of impulses. In the heart, lidocaine reduces depolarisation of the ventricles during diastole and automaticity in the His-Purkinje system. Duration of action potential and effective refractory period are also reduced.