Chloramphenicol + Chlorbutol eye prep

Indications

Chloramphenicol + Chlorbutol eye prep is used for: Ocular infections

Adult Dose

Ophthalmic Ocular infections Adult: Instill 1 drop of a 0.5% solution every 2 hr. Increase dosage interval upon improvement. To continue treatment for at least 48 hr after complete healing. Reduce dose once symptoms are controlled or apply a 1% ointment 3-4 times daily.

Child Dose

Renal Dose

Administration

Contra Indications

History of hypersensitivity

Precautions

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Chloramphenicol + Chlorbutol eye prep : Hypersensitivity reactions including rashes, fever and angioedema.

Mechanism of Action

Chloramphenicol inhibits bacterial protein synthesis by binding to 50s subunit of the bacterial ribosome, thus preventing peptide bond formation by peptidyl transferase. It has both bacteriostatic and bactericidal action against H. influenzae, N. meningitidis and S. pneumoniae.