Chloramphenicol + Dexamethasone + Polymyxin B Eye prep
Indications
Chloramphenicol + Dexamethasone + Polymyxin B Eye prep is used for:
Allergic conjunctivitis, squamous blepharitis, iritis, uveitis, scleritis, keratitis & pre/post-operatively.
Adult Dose
Ophthalmic
Adult:
Eye Ointment
Apply 1/2 inch ribbon 2-3 times daily or as recommended.
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity
Precautions
Prolonged use of topical anti-bacterial agents may give rise to overgrowth of nonsusceptible organisms including fungi
Prolonged use of corticosteroids may result in glaucoma with damage to the optic nerve, defects in visual acuity and fields of vision, and in posterior subcapsular cataract formation
Prolonged use may also suppress the host immune response and thus increase the hazard of secondary ocular infections
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Chloramphenicol + Dexamethasone + Polymyxin B Eye prep :
Blurred vision
Cataract
Raised intraocular pressure
Stinging
Conjunctival hemorrhage
Glaucoma
Vitreous detachment
Hives
Rash
Itching
Mechanism of Action
Polymyxin B alters permeability of cell membranes, which in turn causes intracellular products to leak
Dexamethasone prevents/reduces irritation & swelling by suppressing normal immune response, decreasing inflammatory mediators and reverses capillary permeability
Chloramphenicol inhibits bacterial protein synthesis by binding to 50s subunit of the bacterial ribosome, thus preventing peptide bond formation by peptidyl transferase. It has both bacteriostatic and bactericidal action against H. influenzae, N. meningitidis and S. pneumoniae.