Chlorhexidine Gluconate 0.2% Gargle

Indications

Chlorhexidine Gluconate 0.2% Gargle is used for: Gingivitis, Mouth sore

Adult Dose

Adult: Mouth/throat Oral hygiene; Gingivitis As 0.2% soln: Rinse w/ 10 mL for about 1 min bid.

Child Dose

Renal Dose

Administration

Contra Indications

Hypersensitivity.

Precautions

Avoid contact w/ middle ear or sensitive tissues and eyes. Do not inject or use in body cavities.Avoid eating, drinking, or brushing your teeth just after using this medication

Pregnancy-Lactation

Interactions

Soaps, other anionic agents, borates, bicarbonates, carbonates, chlorides, citrates, nitrates, phosphates & sulfates.

Adverse Effects

Side effects of Chlorhexidine Gluconate 0.2% Gargle : Skin sensitivity; mucosal irritation; reversible brown staining of the teeth; tongue discoloration and burning sensation; transient taste disturbance; parotid gland swelling. Potentially Fatal: Anaphylaxis.

Mechanism of Action

Chlorhexidine is a very potent cationic chemoprophylactic agent that has a broad-spectrum of activity against gm+ve and gm-ve bacteria. It is both bacteriostatic and bactericidal depending on its concentration. The bactericidal effect, which is achieved at high concentrations, is due to the binding of the cationic to negatively charged bacterial cell walls and extramicrobial complexes. Bacteriostatic effect is achieved at low concentrations which causes an alteration of bacterial cell osmotic equilibrium and leakage of potassium and phosphorus.