Ciclopirox + Fluocinolone Topical
Indications
Ciclopirox + Fluocinolone Topical is used for:
Steroid responsive dermatoses with secondary fungal infection.
Adult Dose
Topical
Apply twice daily to affected areas; continue for 1-2 weeks after symptoms subside.
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity; occlusive wrappings/dressings.
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Ciclopirox + Fluocinolone Topical :
Pruritus, burning sensation; headache, rash, irritation, dryness.
Mechanism of Action
Corticosteroids decrease inflammation by stabilizing leukocyte lysosomal membranes, preventing release of destructive acid hydrolases from leukocytes; inhibiting macrophage accumulation in inflamed areas; reducing leukocyte adhesion to capillary endothelium; reducing capillary wall permeability and edema formation; decreasing complement components; antagonizing histamine activity and release of kinin from substrates; reducing fibroblast proliferation, collagen deposition, and subsequent scar tissue formation
Ciclopirox has a wide spectrum of antifungal activity and some antibacterial activity. Inhibits most Candida, Epidermophyton, Microsporum, Trichophyton species and M. furfur by inhibiting transport of essential elements in fungal cells, thus disrupting DNA, RNA and protein synthesis.