Clindamycin + Benzoyl Peroxide

Indications

Clindamycin + Benzoyl Peroxide is used for: Acne vulgaris.

Adult Dose

Topical/Cutaneous Acne vulgaris Adult: Apply to the affected areas once or twice daily (morning and evening). after the skin is gently washed and patted dry.

Child Dose

Renal Dose

Administration

Apply to the affected areas after the skin is gently washed and patted dry.

Contra Indications

History of regional enteritis or ulcerative colitis or history of antibiotic-associated colitis.

Precautions

Avoid contact w/ mouth, eyes, lips & mucous membranes; abraded or eczematous skin. May discolor hair & dyed fabrics. Pregnancy & lactation. Lactation: Excretion in milk unknown/not recommended

Pregnancy-Lactation

Interactions

May enhance the action of neuromuscular blocking agents (e.g. atracurium). May antagonise the effects of parasympathomimetics. May competitively inhibit the effects of macrolides, ketolides, streptogramins, linezolid and chloramphenicol. Increased coagulation tests (prothrombin time/INR) and/or bleeding w/ vit K antagonists (e.g. warfarin, acenocoumarol, fluindione). PABA sunscreens may transiently discolour fabric.

Adverse Effects

Side effects of Clindamycin + Benzoyl Peroxide : Application site pain,Application site exfoliation,Application site irritation,Erythema,Burning,Pruritus,Sunburn,Scaling,Dryness,Diarrhea,Colitis,Peeling

Mechanism of Action

Clindamycin is a semi-synthetic derivative of lincomycin. It inhibits bacterial protein synthesis by reversibly binding to the 50S ribosomal subunits thus blocking the transpeptidation or translocation reactions of susceptible organisms. Benzoyl peroxide has mild keratolytic effect and antimicrobial activity which is attributed to its potent oxidizing activity. Clindamycin and Benzoyl peroxide are both active against Propionibacterium acnes, an organism associated with acne vulgaris.