Clobetasol Propionate 0.05% + Salicylic Acid 3% topical
Indications
Clobetasol Propionate 0.05% + Salicylic Acid 3% topical is used for:
Psoriasis, Burns, Acne vulgaris, Eczema, Dyskeratosis, Ichthyosis, Warts, Hyperkeratosis, Corn, Callus, Seborrhea, Scaly skin disease, Hair loss, Sweating feet, Dermatitis
Adult Dose
Adult: Topical Acne; Hyperkeratotic and scaling skin conditions: Apply >3 times/day.
Warts and calluses: Apply as directed.
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity
Precautions
Not for prolonged use in high concentrations and on large areas of the body. Impaired peripheral circulation or diabetes. Avoid broken skin, mouth, eyes, mucous membranes and anogenital region.
Pregnancy-Lactation
Interactions
Clobetasol Propionate: Increased systemic exposure w/ CYP3A4 inhibitors (eg ritonavir & itraconazole).
Adverse Effects
Side effects of Clobetasol Propionate 0.05% + Salicylic Acid 3% topical :
Prolonged usage of large amount of clobetasol propionate can lead to sufficient systemic levels to produce adrenal suppression, Cushing's syndrome, diabetes and hypertension.Dermal and epidermal atrophy esp on the face, steroid purpura
Mechanism of Action
Clobetasol Propionate high potency corticosteroid. Corticosteroids decrease inflammation by stabilizing leukocyte lysosomal membranes, preventing release of destructive acid hydrolases from leukocytes; inhibiting macrophage accumulation in inflamed areas; reducing leukocyte adhesion to capillary endothelium; reducing capillary wall permeability and edema formation; decreasing complement components; antagonizing histamine activity and release of kinin from substrates; and reducing fibroblast proliferation, collagen deposition, and subsequent scar tissue formation.
Salicylic acid has a potent keratolytic action and a slight antiseptic action when applied topically. It softens and destroys the stratum corneum by increasing endogenous hydration which causes the horny layer of the skin to swell, soften, and then desquamate. At high concentrations, salicylic acid has a caustic effect. It also possesses weak antifungal and antibacterial activity.