Clotrimazole 1% + Hydrocortisone 1%

Indications

Clotrimazole 1% + Hydrocortisone 1% is used for: Athlete's foot, Tinea pedis, Candida nappy rash, Fungal infections, Jock itch, Ringworm, Tinea cruris, Tinea corporis

Adult Dose

Topical/Cutaneous Inflammatory skin fungal infections Adult: As cream: Apply thinly and evenly to the affected area bid and rub in gently. Max duration: 7 days. Max: 10 mg/kg; 500 mg for 50 kg adult equivalent to approx 2 cm to be divided into 2 applications per day. Elderly: Use minimum quantity for the shortest duration.

Child Dose

Child: Require shorter course of treatment.

Renal Dose

Administration

Contra Indications

Hypersensitivity.

Precautions

Avoid contact with eyes upon topical application. Childn <3 yrs. Pregnancy, lactation.

Pregnancy-Lactation

Interactions

Antagonism with polyene antibiotics. Thiazides may enhance hyperglycaemia and hypokalaemia caused by corticosteroids. Increased incidence of peptic ulcer or GI bleeding with concurrent NSAIDs admin. Response to anticoagulants altered. Dose of antidiabetics and antihypertensives needs to be increased. Decreases serum conc of salicylates and antimuscarinic agents. Ethanol may enhance gastric mucosal irritation. Reduced efficacy with concurrent use of carbamazepine, phenytoin, primidone, barbiturates and rifampicin. Mutual inhibition of metabolism between ciclosporin and corticosteroids increase plasma conc of both drugs. Enhanced effect in women taking oestrogens or oral contraceptives.

Adverse Effects

Side effects of Clotrimazole 1% + Hydrocortisone 1% : Topical: Erythema, stinging, irritation; hypersensitivity reactions; contact dermatitis.

Mechanism of Action

Clotrimazole is a broad-spectrum antifungal which binds to phospholipids in the cell membrane altering cell wall permeability causing a loss in essential intracellular elements. Hydrocortisone is a corticosteroid used for its anti-inflammatory and immunosuppressive effects. Its anti-inflammatory action is due to the suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability. It may also be used as replacement therapy in adrenocortical insufficiency.