Clotrimazole + Beclomethasone + Neomycin Topical
Indications
Clotrimazole + Beclomethasone + Neomycin Topical is used for:
Dermatoses where secondary bacterial and candidal infection present.
Adult Dose
Topical/Cutaneous
Corticosteroid-responsive dermatoses
Adult: Apply cream/ointment onto affected area bid or tid.
Child Dose
Safety and efficacy not established
Renal Dose
Administration
Contra Indications
Hypersensitivity.
Precautions
For external use only.
Children, elderly; pregnancy and lactation.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Clotrimazole + Beclomethasone + Neomycin Topical :
Loss of skin collagen and SC atrophy; local hypopigmentation of deeply pigmented skin; local irritation, burning, contact dermatitis
Mechanism of Action
Beclometasone controls the rate of protein synthesis, depresses the migration of polymorphonuclear leukocytes, fibroblasts, reverses capillary permeability and lysosomal stabilisation at the cellular level to prevent or control inflammation.
Clotrimazole is a broad-spectrum antifungal which binds to phospholipids in the cell membrane altering cell wall permeability causing a loss in essential intracellular elements.
Neomycin interferes w/ bacterial protein synthesis by binding to 30S ribosomal subunits.