Clotrimazole + Lidocaine ear prep
Indications
Clotrimazole + Lidocaine ear prep is used for:
Treatment of fungal ear infections.
Adult Dose
Aural
Instill 2 to 4 drops into the affected ear 3 to 4 times daily.
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Clotrimazole + Lidocaine ear prep :
Common side effects such as itching or burning sensations in the ears may occur. Consult your physician immediately if any of these side effects persist or worsen, or if you notice any unusual symptoms after applying these ear drops.
Mechanism of Action
Clotrimazole: Clotrimazole is a synthetic imidazole derivative. Clotrimazole acts against fungi by inhibiting 14α demethylase enzyme thus prevent the conversion of lanosterol to ergosterol. Inhibition of ergosterol synthesis therefore, leads to structural and functional impairment of the fungal cytoplasmic membrane.
Lidocaine: Lidocaine (Lignocaine) is commonly applied topically for its strong local anesthetic properties. It has been proven to reduce pain in the auditory canal in patients affected by acute ear infections. Lidocaine alters signal conduction in neurons by blocking the fast voltage gated sodium (Na+) channels in the neuronal cell membrane that are responsible for signal propagation.