Desloratadine + Pseudoephedrine Sulphate

Indications

Desloratadine + Pseudoephedrine Sulphate is used for: Allergic rhinitis, Itching, Sneezing, Watery eyes, Runny nose, Hives, Skin rash, Common cold, Nasal congestion

Adult Dose

PO: Adults: 1 tablet (2.5 mg desloratadine/120 mg pseudoephedrine) 12 hourly. 1 tablet (5 mg desloratadine/240 mg pseudoephedrine) 24 hourly. Hepatic Impairment Not recommended

Child Dose

PO: Child: 12 years or over : 1 tablet (2.5 mg desloratadine/120 mg pseudoephedrine) 12 hourly. 1 tablet (5 mg desloratadine/240 mg pseudoephedrine) 24 hourly.

Renal Dose

Not recommended

Administration

May be taken with or without food: Swallow whole, do not chew/break/crush.

Contra Indications

Hypersensitivity.

Precautions

Severe renal or hepatic failure; children <6 mth, elderly, epilepsy, pregnancy and lactation. Lactation: both drugs pass into breast milk, pseudoephedrine is concentrated in breast milk; use caution

Pregnancy-Lactation

Interactions

Potential increase in plasma concentrations w/ drugs affecting hepatic microsomal enzymes (e.g. azithromycin, cimetidine, erythromycin, fluoxetine, ketoconazole). Increased risk of hypertension and arrhythmias if given with cardiac glycosides, quinidine or TCAs. Increased risk of vasoconstrictor effects if given with ergot alkaloids or oxytocin. Co-admin with MAOIs may cause hypertensive crisis. Anaesthetics e.g. cyclopropane, halothane and other halogenated anaesthestics; antihypertensive agents.

Adverse Effects

Side effects of Desloratadine + Pseudoephedrine Sulphate : >10% Desloratadine Fever (12%),Irritability (12%),Headache (12%),Diarrhea (15-21%),Cough (11%),Upper respiratory tract infection (11-21%) 1-10% Desloratadine Pharyngitis (4.1%),Dry mouth (3%),Myalgia (2.1%),Emotional lability (3%),Erythema (3%),Macopapular rash (3%),Dizziness (4%),Fatigue (2.1%),Somnolence (2.1%)Urinary tract infection (4%),Dyspepsia (3%),Insomnia (5%),Dysmenorrhea (2.1%) Frequency Not Defined Pseudoephedrine CNS (tremor, restlessness, etc),Insomnia,Arrhythmia,Hypotension,Tachycardia,Fatigue,Rash,Urticaria,Anorexia,Xerostomia,Dysuria,Polyuria,Nausea,Vomiting,Ischemic colitis

Mechanism of Action

Desloratadine is a long-acting, tricyclic, non-sedating, selective peripheral histamine H1-receptor antagonist which inhibits the release of pro-inflammatory mediators from human mast cells and basophils. Pseudoephedrine is both an ?-and ?-adrenergic receptor agonist. It causes vasoconstriction via direct stimulation of ?-adrenergic receptors of the respiratory mucosa. It also directly stimulates ?-adrenergic receptors causing bronchial relaxation, increased heart rate and contractility.