Dexamethasone 0.1% + Neomycin 0.35% + Polymixin B (Eye prep)

Indications

Dexamethasone 0.1% + Neomycin 0.35% + Polymixin B (Eye prep) is used for: Bacterial eye infections, Ocular inflammation

Adult Dose

Ophthalmic Ocular inflammation with suspected or confirmed bacterial infection Adult: Eye drops: Instill 1-2 drops in the conjunctival sac(s) of the affected eye(s) up to 4-6 times daily; may be used up to hrly in severe disease. Reduce frequency once condition improves.

Child Dose

Renal Dose

Administration

Contra Indications

Hypersensitivity. Epithelial herpes simplex keratitis (dentritic keratitis), vaccinia, varicella, and many other viral diseases of the cornea and conjunctiva. Hypersensitivity to a component of the medication (Hypersensitivity to the antibiotic component occurs at a higher rate than other component). The use of these combinations is always contraindicated after uncomplicated removal of a corneal foreign body.

Precautions

Prolonged use may cause glaucoma, damage to the optic nerve, defects in visual acuity and fields of vision, posterior subcapsular cataract formation and increased risk of secondary ocular infections. Increased risk of perforations in diseases which can cause thinning of the cornea or sclera. Corticosteroids may mask infection or worsen existing infections in acute purulent conditions of the eye. Regular monitoring of the intraocular pressure is recommended if product is used for ?10 days. Long term application of topical corticosteroids may also increase the risk of ocular fungal infections. Neomycin sulfate may cause cutaneous sensitisation. Pregnancy and lactation. Lactation: Unknown if excreted in breastmilk; minimal systemic absorption with ophthalmic administration

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Dexamethasone 0.1% + Neomycin 0.35% + Polymixin B (Eye prep) : Blurred vision,Cataract,Raised intraocular pressure,Stinging,Conjunctival hemorrhage,Glaucoma,Vitreous detachment,Hives,Rash,Itching,Eye pain

Mechanism of Action

Dexamethasone is a corticosteroid with mainly glucocorticoid activity; it is used topically mainly for its anti-inflammatory action. Neomycin is a broad-spectrum aminoglycoside antibiotic that is used topically for the treatment of infections of the skin, ear and eye due to susceptible staphylococci and other organisms. Polymyxin B is active only against gram-negative bacteria especially Pseudomonas aeruginosa.