Dexlansoprazole

Indications

Dexlansoprazole is used for: Oesophagitis, Gastro-oesophageal reflux disease (GERD)

Adult Dose

Erosive Esophagitis Capsule: Indicated for healing of all grades of erosive esophagitis (EE) and maintaining healing of EE DR: Indicated for maintaining healing of EE Healing (capsule): 60 mg PO qDay for up to 8 weeks Maintenance (capsule or DR): 30 mg PO qDay for up to 6 months Gastroesophageal Reflux Disease Indicated for treating heartburn associated with symptomatic nonerosive GERD Capsule or DR: 30 mg PO qDay for 4 weeks Hepatic impairment Milde (Child-Pugh A): Dose adjustment not necessary Moderate (Child-Pugh B): Not to exceed 30 mg/day Severe (Child-Pugh C): Not recommended

Child Dose

<12 years Safety and efficacy not established >12 years Erosive Esophagitis Capsule: Indicated for healing of all grades of erosive esophagitis (EE) and maintaining healing of EE DR: Indicated for maintaining healing of EE Healing (capsule): 60 mg PO qDay for up to 8 weeks Maintenance (capsule or DR): 30 mg PO qDay for up to 6 months Gastroesophageal Reflux Disease Indicated for treating heartburn associated with symptomatic nonerosive GERD Capsule or DR: 30 mg PO qDay for 4 weeks

Renal Dose

Administration

Capsule: May take with or without food DR: Take at least 30 minutes before a meal

Contra Indications

Hypersensitivity.

Precautions

Hepatic impairment. Gastric malignancy should be ruled out. Pregnancy and lactation. Lactation: Not known whether distributed into breast milk; discontinue nursing or drug

Pregnancy-Lactation

Interactions

Increased risk of hypomagnesaemia w/ diuretics and digoxin. May decrease plasma concentration of erlotinib, dasatinib and lapatinib. May decrease the bioavailability of itraconazole and ketoconazole. May increase plasma concentration of cilostazol and methotrexate. Reduced bioavailability w/ antacids and sucralfate. Potentially Fatal: May decrease serum levels and pharmacological effects of rilpivirine and atazanavir.

Adverse Effects

Side effects of Dexlansoprazole : 1-10% Diarrhea (5%),Abdominal pain (4%),Nausea (3%),URI (2-3%),Vomiting (1-2%),Flatulence (1%) <1% (Selected) Arrhythmia,Bradycardia,Barrett's esophagus,DVT,Dyspnea,Hepatomegaly,Hypertension,Paresthesia,Rectal hemorrhage,Vulvovaginal infection

Mechanism of Action

R-enantiomer of lansoprazole; PPI; binds to H+/K+-exchanging ATPase (proton pump) in gastric parietal cells, resulting in blockage of acid secretion.Dual release formulation.