Dextromethorphan + Phenylpropanolamine + Pheniramine
Indications
Dextromethorphan + Phenylpropanolamine + Pheniramine is used for:
Cough suppression, dry cough
Adult Dose
Oral
Cough suppression
Adult: 2-3 tsf 2-3 times daily
Child Dose
Oral
Cough suppression
Child.12 years: 2-3 tsf 2-3 times daily
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Symptomatic prostatic hypertrophy; neonates and premature infants.
Precautions
Treatment with a cough medicine in children (especially under 12 years old) should be considered carefully due to potential risks and limited evidence on efficacy. Pregnancy and lactation. May impair ability to drive or operate machinery. Has potential for abuse. Narrow angle glaucoma, asthma or severe CV disease. Antiemetic effect may mask signs of other conditions.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Dextromethorphan + Phenylpropanolamine + Pheniramine :
Gastrointestinal disorders: Abdominal pain, diarrhoea, gastrointestinal disturbance, nausea, vomiting. Nervous system disorders: Dizziness, drowsiness, convulsion, psychomotor hyperactivity, somnolence, serotonin syndrome, excitement, nervousness. Psychiatric disorders: Insomnia, confusional state. Respiratory, thoracic and mediastinal disorders: Respiratory depression.
Mechanism of Action
Dextromethorphan, a centrally-acting antitussive agent, depresses the medullary cough centre through sigma receptor stimulation, resulting to decreased sensitivity of cough receptors and interruption of cough impulse transmission.
Pheniramine is an alkylamine derivative with histamine H1-receptor antagonist effects. It also has anticholinergic and moderate sedative effects.