Diacerein

Indications

Diacerein is used for: Osteoarthritis, Musculoskeletal and joint disorders

Adult Dose

Oral Osteoarthritis Adult: 50 mg bid.

Child Dose

Renal Dose

Renal impairment: CrCl (ml/min) Dosage Recommendation <30 25 mg daily.

Administration

Should be taken with food. Take w/ or immediately after meals.

Contra Indications

Pregnancy, lactation. Hypersensitivity to anthraquinone derivatives.

Precautions

Renal impairment. Monitor CBC, LFT and urinalysis every 6 mth.

Pregnancy-Lactation

Interactions

Decreased absorption with aluminium and/or magnesium hydroxide antacids. Increased risk of diarrhoea with laxatives, antibiotics. Avoid co-admin with fibres and phytates.

Adverse Effects

Side effects of Diacerein : Diarrhoea, epigastric pain, nausea, vomiting, intense yellow colouring of urine.

Mechanism of Action

Diacerein is an anthraquinone derivative that has been used in osteoarthritis. It is thought to act via inhibition of interleukin-1β.