Diatrizoic Acid
Indications
Diatrizoic Acid is used for:
Intravenous & retrograde urography, all types of angiography & other special examinations.
Adult Dose
Dosage depends on the type & location of the investigation.
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
High osmolal radiocontrast agents like diatrizoate are cytotoxic to renal cells. The toxic effects include apoptosis, cellular energy failure, disruption of calcium homeostasis, and disturbance of tubular cell polarity, and are thought to be linked to oxidative stress.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Diatrizoic Acid :
Mechanism of Action
Diatrizoate is an iodine-containing X-ray contrast agent. Iodated contrast agents were among the first contrast agents developed. Iodine is known to be particular electron-dense and to effectively scatter or stop X-rays. A good contrast agent requires a high density of electron-dense atoms. Therefore, the more iodine, the more "dense" the x-ray effect. Iodine based contrast media are water soluble and harmless to the body. These contrast agents are sold as clear colorless water solutions, the concentration is usually expressed as mg I/ml. Modern iodinated contrast agents can be used almost anywhere in the body. Most often they are used intravenously, but for various purposes they can also be used intraarterially, intrathecally (the spine) and intraabdominally - just about any body cavity or potential space.