Diclofenac + Methyl Salicylate topical
Indications
Diclofenac + Methyl Salicylate topical is used for:
Low back pain, spondylitis, arthropathies & arthritis pain.
Adult Dose
Topical
Adult
Apply 2-4 g (4-8 cm strip) on skin & rub lightly bd-tds into the affected area.
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity. Aspirin-induced bronchial asthma. Avoid use on broken skin, & open wound. Childn <12 yr.
Precautions
Hypersensitivity to local use of ASA, different salicylates & other NSAIDs. Patients w/ stomach or intestinal ulcer, liver & kidney disorders, haematological disorders, nasal polyposis relapse. Do not apply on damaged skin. Wash hands after use; avoid contact w/ eyes & mucous tunics. Do not apply on big areas of the body, or use for a long time in the last 3 mth of pregnancy & during lactation. Neonates.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Diclofenac + Methyl Salicylate topical :
Skin irritation, eg, skin rash, oedema, wheals, papules, scutes, reddening, burning, prickling, itch at the application site.
Mechanism of Action
Diclofenac inhibits the cyclooxygenase, suppresses synthesis of prostaglandins-endogenous substances, which play a significant role in the genesis of the inflammation, pain, and fever. Diclofenac reduces pain, eliminates inflammation.
Methyl salicylate is a derivative of salicylic acid, which has local irritation action. Methyl salicylate decreases the pain because of irritation of skin receptors. Methyl salicylate inhibits synthesis of prostaglandins, decreases swelling and infiltration of inflamed tissues.