Diclofenac + Paracetamol

Indications

Diclofenac + Paracetamol is used for: Pain and inflammation associated with musculoskeletal and joint disorders

Adult Dose

Oral Pain and inflammation associated with musculoskeletal and joint disorders Adult: Per tablet contains diclofenac sodium 50 mg and paracetamol 500 mg. 1 tablet tid.

Child Dose

Renal Dose

Administration

Should be taken with food

Contra Indications

Hypersensitivity, active peptic ulcer or GI bleeding, history of allergic responses to aspirin or other NSAIDs, acute porphyria.

Precautions

Analgesic nephropathy, renal or hepatic impairment, hypertension, cardiac failure, bronchospasm, patients taking diuretics and elderly, lactation.

Pregnancy-Lactation

Interactions

Potentiates potassium-sparing diuretics. Reduced serum levels of salicylates. Potentially Fatal: Increased levels of lithium, digoxin and methotrexate.

Adverse Effects

Side effects of Diclofenac + Paracetamol : GI disturbances, nephrotic syndrome, epigastric pain, nausea, vomiting, diarrhoea, hepatitis, rash, pruritus, wheezing, bronchospasm, prolonged bleeding time. Potentially Fatal: Bleeding or perforation through peptic ulcer, rarely blood dyscrasia or anaphylaxis, acute renal failure.

Mechanism of Action

Diclofenac is a NSAID (NSAID). Paracetamol is an analgesic and antipyretic. When used together, the actions of paracetamol set in earlier and provides pain relief before the effects of diclofenac Na set in.