Diloxanide furoate + Tinidazole
Indications
Diloxanide furoate + Tinidazole is used for:
Intestinal amoebiasis, amoebic hepatitis, nondysentric amoebic colitis, asymptomatic cyst passers.
Adult Dose
Oral
Adult
2 tabs bid for 5 days.
Child Dose
Renal Dose
Administration
Should be taken with food. Take during or immediately after meals.
Contra Indications
Hypersensitivity
Precautions
Pregnancy and lactation.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Diloxanide furoate + Tinidazole :
Transient leucopenia, ataxia, convulsions, dizziness, headache, hypesthesia, paraesthesia, peripheral neuropathy, sensory disturbances, vertigo, metallic taste, flushing, abdominal pain, anorexia, diarrhoea, furry tongue, glossitis, nausea, stomatitis, vomiting, dark urine, fever, tiredness.
Mechanism of Action
Diloxanide is a luminal amoebicide which is hydrolysed in the gut, thus releasing the free diloxanide which acts as an amoebicide. It is given alone in asymptomatic cyst passers. For patients with active amoebic infections, it can be administered with a 5-nitroimidazole e.g. metronidazole or tinidazole.
Tinidazole, a 5-nitroimidazole derivative w/ antimicrobial actions similar to metronidazole, is active against both protozoa (e.g. Trichomonas vaginalis, Entamoeba histolytica and Giardia lamblia) and obligate anaerobic bacteria. It damages DNA strands or inhibits DNA synthesis in microorganism.