Diosmin
Indications
Diosmin is used for:
Haemorrhoids, varicose veins, menorrhagia, metrorrhagia, IUD intolerance & functional venous disorders, venous insufficiency, heavy & painful legs, edema & tight calves & painful varicose.
Adult Dose
Adult
Tablet
600-1200 mg/day after meals.
Acute disorders eg. haemorrhoids: 4 tabs tid for 2-3 days.
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity to any of the substances present in the drug.
Precautions
Pregnancy & Lactation.
Pregnancy-Lactation
Interactions
Metabolism of metronidazole may be reduced by concurrent admin of diosmin.
Adverse Effects
Side effects of Diosmin :
Possible side-effects to be observed: cutaneous allergies, gastrointestinal disorders, headaches and flushes.
Mechanism of Action
Diosmin is flavonoid compounds. When used together, they prolong the vasoconstrictor effect of noradrenaline on the venous wall, thus increasing venous return and reducing venous hyperpressure present in patients with chronic venous disease. They also improve lymphatic drainage and protect the microcirculation from inflammation. Diosmin is used together in the treatment of venous disease e.g. chronic venous disease and haemorrhoidal disease.