Diosmin + Hesperidin
Indications
Diosmin + Hesperidin is used for:
Hemorrhoids, Piles, Chronic venous disease
Adult Dose
Oral
Chronic venous disease
Adult: Each tablet containing disomin 450 mg and hesperidin 50 mg: 2 tablets daily.
Haemorrhoids
Adult: Acute attack: 6 tablets daily for the 1st 4 days followed by 4 tablets daily for the next 3 days.
Chronic haemorrhoids: 2 tablets daily.
Child Dose
Renal Dose
Administration
Contra Indications
It is contra-indicated in patients, who have shown hypersensitivity to any of the substances present in the drug.
Precautions
Pregnancy & Lactation.
Pregnancy-Lactation
Interactions
Metabolism of metronidazole may be reduced by concurrent admin of diosmin.
Adverse Effects
Side effects of Diosmin + Hesperidin :
Possible side-effects to be observed: cutaneous allergies, gastrointestinal disorders, headaches and flushes.
Mechanism of Action
Diosmin and hesperidin are flavonoid compounds. When used together, they prolong the vasoconstrictor effect of noradrenaline on the venous wall, thus increasing venous return and reducing venous hyperpressure present in patients with chronic venous disease. They also improve lymphatic drainage and protect the microcirculation from inflammation. Diosmin and hesperidin are used together in the treatment of venous disease e.g. chronic venous disease and haemorrhoidal disease.