Diphtheria Toxoid 30 IU + Tetanus Toxoid 40 IU
Indications
Diphtheria Toxoid 30 IU + Tetanus Toxoid 40 IU is used for:
Diphtheria, tetanus
Adult Dose
Primary Immunization (not previously immunized):
2 primary doses of 0.5 mL IM each given at an interval of 4 weeks with a third dose (0.5 mL) 6 months later
Booster Immunization
0.5 mL every 10 years (patients that have completed primary immunization)
Child Dose
Primary Immunization
<7 years
Three doses: 0.5 mL (DT) at 2, 4, and 6 months of age; may administer as early as 6 weeks of age and repeated every 4-8 weeks
Fourth dose: At least 6 months must elapse between the third and fourth dose; may give as early as 12 months of age if 6 months have passed since the third dose
Fifth dose: 4-6 years of age prior to starting school or kindergarten; may omit this dose if fourth dose given >4 years of age
>7 years (not previously immunized): 2 primary doses of 0.5 mL IM each given at an interval of 4 weeks with a third dose (0.5 mL) 6 months later
Booster Immunization
0.5 mL every 10 years (patients that have completed primary immunization)
Renal Dose
Administration
Contra Indications
A severe allergic reaction (e.g., anaphylaxis) after a previous dose of any tetanus toxoid-, diphtheria toxoid-, or pertussis antigen-containing vaccine or any component of this vaccine is a contraindication to administration.
Progressive encephalopathies, with or without convulsions.
A severe reaction occurring within 48 hrs of a previous vaccine injection: Fever ?40°C; persistent crying syndrome; febrile or afebrile convulsions; hypotonic-hyporesponsive syndrome.
Precautions
A history of febrile convulsions not related to a previous vaccination does not constitute per se sufficient grounds for contraindication to immunization.
As with all injectable vaccines, appropriate medical treatment and supervision should be readily available for immediate use in case of a rare anaphylactic reaction following the administration of vaccine.
Haemophilus influenzae type b valence, the 2 vaccines, diphtheria-tetanus-pertussis-poliomyelitis and the H. influenzae type b conjugate vaccine, should be administered at 2 separate injection sites and on 2 different days.
Lactation: Excretion in milk unknown; use with caution
Pregnancy-Lactation
Interactions
Immune response to vaccines may be reduced in patients who are receiving immunosuppressive treatment e.g. cytotoxics, high dose corticosteroids, irradiation.
Adverse Effects
Side effects of Diphtheria Toxoid 30 IU + Tetanus Toxoid 40 IU :
>10%
Headache (34-40%),Tiredness (21-27%),Chills (7-13%),Diarrhea (10-11%),Nausea (8-12%),Swelling (17-18%),Sore/swollen joints (7-12%),Tenderness, pain, redness, swelling at inj site (63%),Arthus reaction (rare)
1-10%
Rash (2%),Lymph node swelling (4-5%),Fever (1-3%),Vomiting (2-3%)
<1%
Myalgia,Paresthesia,Seizure,Chils,Dizziness,Fatigue,Lymphadenopathy,Musculosckeletal stiffness
Mechanism of Action
Vaccine is used for the active immunisation of diphtheria, tetanus.