Diphtheria Toxoid 30IU + Tetanus Toxoid 60IU + Pertusis + Hepatitis B (Vaccine)
Indications
Diphtheria Toxoid 30IU + Tetanus Toxoid 60IU + Pertusis + Hepatitis B (Vaccine) is used for:
Diphtheria, Tetanus, Pertussis & Hepatitis B in infants.
Adult Dose
Child Dose
Immunization
Diphtheria, tetanus, pertussis, hepatitis B
Deep IM inj
Primary vaccination 3 doses of 0.5 mL w/in the 1st 6 mth of life at intervals of at least 4 wk.
Booster dose: Administer during the 2nd yr of life.
Renal Dose
Administration
Contra Indications
Previous encephalopathy after pertussis vaccine; acute severe febrie illness.Hypersensitivity to any component of the vaccine. Childn w/ history of encephalopathy of unknown etiology occurring w/in 7 days following previous vaccination. Do not administer IV.
Precautions
Previous reaction to DTP vaccine; family history of convulsions, SIDS; bleeding disorders; immunosuppression /deficiency; pregnancy, lactation. Postpone vaccination in patients w/ acute severe febrile illness. Should be administered SC in patients w/ thrombocytopenia or bleeding disorders. Syncope, risk of apnea. Temp >40°C, persistent crying lasting >3 hr & collapse or shock-like state w/in 48 hrs; convulsions w/ or w/o fever w/in 3 days. High incidence of pertussis. Childn w/ progressive neurological disorders including infantile spasms, uncontrolled epilepsy or progressive encephalopathy. Consider potential risk of apnea & need for resp monitoring for 48-72 hr to very premature infants (>28 wk of gestation) particularly those w/ previous history of resp immaturity.
Lactation: Not indicated for women of childbearing age
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Diphtheria Toxoid 30IU + Tetanus Toxoid 60IU + Pertusis + Hepatitis B (Vaccine) :
>10%
Irritability/fussiness (61-65%),Drowsiness (41-57%),Fever (28-39%),Loss of appetite (26-31%),Swelling (17-29%)
1-10%
Fever (≤1%)
<1%
Anorexia,Apnea,Erythema,Decreased consciousness,Diarrhea,Hypotonia,Encephalitis,Brachial neuritis,Erythema,Peripheral neuropathy,Cough,Lethargy,Limb pain,Liver function test abnormalities,Rash,Restlessness
Mechanism of Action
Vaccine is used for the active immunisation of diphtheria, tetanus and pertussis in children from 6 wk to 6 yr of age. Production of specific antibodies to tetanus, diphtheria, and pertusis (active immunity). Conveys active immunity via stimulation of production of endogenously produced antibodies