Econazole Nitrate 1%
Indications
Econazole Nitrate 1% is used for:
Tinea pedis, Tinea cruris, Tinea corporis, Jock itch, Athlet's foot, Pityriasis versicolor, Cutaneous candidiasis, Onychomycoses.
Adult Dose
Topical/Cutaneous
Nail fungal infections
Adult: As 1% cream or lotion: Apply once daily under occlusive dressing. For tinea pedis: As 1% cream or foam: Apply once daily for 4 wk.
Tinea cruris; Tinea versicolor; Tinea corporis
Adult: As 1% cream: Apply once daily for 2 wk.
Cutaneous candidiasis
Adult: As 1% cream: Apply bid (morning and evening) for 2 wk.
Child Dose
<3 months: Safety and efficacy not established
Tinea pedis, cruris, corporis, versicolor:
Apply cream to affected area(s) qDay
Cutaneous candidiasis:
Apply cream to affected area(s) BID
Renal Dose
Administration
Contra Indications
Hypersensitivity.
Precautions
Avoid contact with eyes and mucous membranes. Pregnancy.
Lactation: excretion in milk unknown; use with caution
Pregnancy-Lactation
Interactions
May enhance anticoagulant effect of warfarin or acenocoumarol.
Adverse Effects
Side effects of Econazole Nitrate 1% :
1-10%
Erythema (3%)
Frequency Not Defined
Burning and stinging sensations, Pruritus
Mechanism of Action
Econazole modifies the permeability of cell wall membrane in fungi; may interfere w/ RNA and protein synthesis, and lipid metabolism.