Econazole Nitrate (Vaginal prep)

Indications

Econazole Nitrate (Vaginal prep) is used for: Vaginal thrush, , Vulvo-vaginal candidiasis or any other fungal infection of vagina.

Adult Dose

Vag candidiasis As VT: 150 mg/day at bedtime for 3 consecutive nights. Vaginal infection As Vaginal cream: Applied with the applicator par vaginally once or twice daily.

Child Dose

Renal Dose

Administration

Contra Indications

Hypersensitivity. Porphyria;

Precautions

Avoid contact with eyes and mucous membranes. May damage latex contraceptives. During pregnancy: There is no information of any abnormality or adverse event in neonates while Econazole Cream / VT had been used during pregnancy. During lactation: As the systemic absorption of Econazole Nitrate cream is extremely low after topical/vaginal use, excretion in breastmilk is likely to be negligible. So, it can be used topically/vaginally during lactation if needed.

Pregnancy-Lactation

Interactions

Theoretical potential for compd metabolized by CYP3A4/2C9, oral anticoagulants eg warfarin & acenocoumarol.

Adverse Effects

Side effects of Econazole Nitrate (Vaginal prep) : Vulvar/vaginal burning; erythema; itching;

Mechanism of Action

Econazole modifies the permeability of cell wall membrane in fungi; may interfere w/ RNA and protein synthesis, and lipid metabolism.