Flunarizine
Indications
Flunarizine is used for:
Migraine, Vertigo, Peripheral vascular disease, Cerebrovascular disorders, Vestibular disorders
Adult Dose
Oral
Prophylaxis of migraine; Prophylaxis of vertigo and vestibular disorders; Prophylaxis of peripheral and cerebrovascular disorders
Adult: 5-10 mg daily at bedtime.
Child Dose
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Pregnancy, lactation, GI or urinary tract obstruction, acute porphyrias.
Precautions
Driving or operating machinery, epilepsy, elderly, CVS disease, glaucoma.
Pregnancy-Lactation
Interactions
Plasma levels reduced by phenytoin, carbamazepine, valproic acid.
Adverse Effects
Side effects of Flunarizine :
Drowsiness. Rarely wt gain, headache, depression, gastric pain, dry mouth, insomnia, extrapyramidal reactions, galactorrhoea.
Mechanism of Action
Flunarizine has H1-receptor blocking action and calcium-channel blocking effect. It has also been used as an adjunct epileptic therapy for patients refractory to standard treatment regimens.