Fusidic Acid
Indications
Fusidic Acid is used for:
Acne vulgaris, Skin infections, Conjunctivitis, staphylococcal infections
Adult Dose
Oral
Susceptible infections
Adult: 500 mg tid. May increase to 1 g tid in fulminating infections.
Ophthalmic
Conjunctivitis
Adult: As 1% eye drops: Instill 1 drop into the affected eye every 12 hr for 7 days.
Child Dose
Oral
Susceptible infections
Child: <1 yr: About 15 mg/kg;
1-5 yr: 250 mg;
5-12 yr: 500 mg.
Doses to be taken tid.
Ophthalmic
Conjunctivitis
Child: >2 yr: As 1% eye drops: Instill 1 drop into the affected eye every 12 hr for 7 days.
Renal Dose
Administration
Should be taken with food.
Contra Indications
Hypersensitivity.
Precautions
Hepatic disease; monitor liver function. Neonates; pregnancy, lactation.
Pregnancy-Lactation
Interactions
Synergistic action with antistaphylococcal penicillin. Antagonism with ciprofloxacin.
Adverse Effects
Side effects of Fusidic Acid :
Jaundice and liver dysfunction (reversible); GI disturbances. IV: Venospasm, thrombophloebitis and haemolysis; hypocalcaemia. SC/IM: Tissue necrosis. Topical: Rashes and irritation.
Mechanism of Action
Fusidic acid disrupts translocation of peptide subunits and elongating the peptide chain of susceptible bacteria, thus inhibiting protein synthesis.