Gadoversetamide
Indications
Gadoversetamide is used for:
Injection is indicated for use with magnetic resonance imaging (MRI) in patients with abnormal blood-brain barrier or abnormal vascularity of the brain, spine and associated tissues.
It also indicated for use with MRI to provide contrast enhancement and facilitate visualization of lesions with abnormal vascularity in the liver in patients who are highly suspect for liver structural abnormalities on computed tomography.
Adult Dose
Kilograms (kg) 40 Pounds (lb)88 Volume (mL)8.0
Kilograms (kg) 50 Pounds (lb)110 Volume (mL)10.0
Kilograms (kg) 60 Pounds (lb)132 Volume (mL)12.0
Kilograms (kg) 70 Pounds (lb)154 Volume (mL)14.0
Kilograms (kg) 80 Pounds (lb)176 Volume (mL)16.0
Kilograms (kg) 90 Pounds (lb)198 Volume (mL)18.0
Kilograms (kg)100 Pounds (lb)220 Volume (mL)20.0
Kilograms (kg) 110 Pounds (lb)242 Volume (mL)22.0
Kilograms (kg) 120 Pounds (lb)264 Volume (mL)24.0
Kilograms (kg) 130 Pounds (lb)286 Volume (mL)26.0
Kilograms (kg) 140 Pounds (lb) 308 Volume (mL) 28.0
Kilograms (kg) 150 Pounds (lb)330 Volume (mL)30.0
Child Dose
Renal Dose
Administration
Contra Indications
- chronic, severe kidney disease (glomerular filtration rate, GFR <30 mL/min/1.73m2), or
- acute kidney injury, or
- known allergic or hypersensitivity reactions to gadolinium, versetamide or any of the inert ingredients.
Precautions
Diagnostic procedures that involve the use of contrast agents should be carried out under direction of a physician with the prerequisite training and a thorough knowledge of the procedure to be performed.
Personnel trained in resuscitation techniques and resuscitation equipment should be available.
The possibility of a reaction, including serious, life threatening, fatal, anaphylactoid or cardiovascular reactions or other idiosyncratic reactions should always be considered especially in those patients with a known clinical hypersensitivity, a history of asthma, or other respiratory disorders .
Some paramagnetic contrast agents may impair the visualization of existing lesions, which are seen on the unenhanced, non-contrast MRI. This may be due to effects of the paramagnetic contrast agent, imaging parameters, misregistration, etc. CAUTION SHOULD BE EXERCISED WHEN A CONTRAST ENHANCED INTERPRETATION IS MADE IN THE ABSENCE OF A COMPANION UNENHANCED MRI.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Gadoversetamide :
Body as a Whole: allergic reaction, edema face, fever, flu-like syndrome, malaise, mucous membrane discharge, neck rigidity, neck pain, pelvic pain, increased sweating
Cardiovascular: arrhythmia, chest pain, hypertension, hypotension, pallor, palpitation, syncope, tachycardia, vasospasm
Digestive: anorexia, increased appetite, constipation, dry mouth, dysphagia, eructation, flatulence, increased salivation, thirst, vomiting
Hemic and Lymphatic: thrombocytopenia
Metabolic and Nutritional: increased creatinine, edema, hypercalcemia, hyperglycemia, hypoglycemia, hyponatremia
Musculoskeletal: arthralgia, leg cramps, myalgia, myasthenia, spasm
Nervous System: agitation, anxiety, confusion, depersonalization, diplopia, dystonia, hallucinations, hypertonia, hypesthesia, nervousness, somnolence, tremor, vertigo
Respiratory System: asthma, cough, dyspnea, epistaxis, hemoptysis, laryngismus, pharyngitis, sinusitis, voice alteration
Skin and Appendages: application site reaction, edema injection site, erythema multiforme, pruritus, rash macular-papular and vesicullous bullous, skin dry, thrombophlebitis, inflammation injection site, urticaria
Special Senses: amblyopia, conjunctivitis, hyperacusis, parosmia, tinnitus
Urogenital: dysuria, oliguria, urine frequency