Glycerol
Indications
Glycerol is used for:
Constipation, Lubrication
Adult Dose
As suppository:
Adults: only one 2.30 gm Suppository per 24 hours or as directed by a physician
Child Dose
As suppository:
Children (2 to 6 years): only one 1.15gm Suppository per 24 hours or as directed by a physician.
Children (From 6 years): only one 2.30gm Suppository per 24 hours or as directed by a physician
Renal Dose
Administration
Insert suppository well up into rectum. Suppository need to melt completely to produce laxative action.
Contra Indications
Hypersensitivity.
Precautions
Hypervolaemia, cardiac failure or renal disease, dehydrated patients, DM.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Glycerol :
Local irritation e.g. rectal discomfort and burning sensation.
Mechanism of Action
Glycerol is an osmotic dehydrating agent that possesses hygroscopic and lubricating properties. It causes plasma osmolality leading to the movement of water into the plasma from the extravascular spaces via osmosis.