Hydrocortisone 0.5% topical
Indications
Hydrocortisone 0.5% topical is used for:
Corticosteroid-responsive dermatoses
Adult Dose
Topical/Cutaneous
Corticosteroid-responsive dermatoses
Adult: As Cream/ointment/lotion: Apply thinly onto affected area(s) once daily - bid.
Child Dose
Renal Dose
Administration
Contra Indications
Underlying infection
Hypersensitivity
Ophthalmic use
Treatment of diaper dermatitis
Precautions
Chronic topical corticosteroid therapy may interfere with growth and development in children
Use lower potency in children; may absorb proportionally larger amounts after topical application and may cause systemic effects
Occlussive dressings, prolonged use, application to large surface areas, or application to denuded skin, may increase percutaneous absorption, which may result in cushing syndrome, glycosuria, and hyperglycemia
Prolonged use may increase risk of Kaposi's sarcoma
Prolonged use may increase risk of secondary infection, may mask acute infection, limit response to vaccines, and prolong or exacerbate viral infections; avoid exposure to measles or chickenpox while receiving therapy; not for the treatment of ocular herpes simplex, cerebral malaria, fungal infections, or viral hepatitis; observe patients with latent tuberculosis closely; restric use in active tuberculosis
Pregnancy-Lactation
There are no adequate and well-controlled studies in pregnant women on teratogenic effects from topically applied corticosteroids; corticosteroids generally teratogenic in laboratory animals when administered systemically at relatively low dosage levels; topical corticosteroids should be used during pregnancy only if potential benefits justify potential risk to fetus; should not be used extensively on pregnant patients, in large amounts, or for prolonged periods of time
Interactions
Adverse Effects
Side effects of Hydrocortisone 0.5% topical :
Skin atrophy
Striae
Acneform lesions
Perioral dermatitis
Folliculitis
Itching
Pigmentation changes
HPA suppression (with higher potency used >2 wk)
Mechanism of Action
Decreases inflammation by stabilizing leukocyte lysosomal membranes, preventing release of destructive acid hydrolases from leukocytes
Inhibits macrophage accumulation in inflamed areas
Reduces leukocyte adhesion to capillary endothelium
Reduces capillary wall permeability and edema formation
Decreases complement components and antagonizes histamine activity and release of kinin from substrates
Reduces fibroblast proliferation, collagen deposition, and subsequent scar tissue formation