Hydrocortisone + Neomycin Sulphate + Polymixin B Eye prep
Indications
Hydrocortisone + Neomycin Sulphate + Polymixin B Eye prep is used for:
Ocular inflammation
Adult Dose
Ophthalmic
Ocular inflammation with suspected or confirmed bacterial infection
Adult: 1-2 drops every 3-4 hrly as indicated.
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity to aminoglycosides and any of its components. Pre-existing nerve deafness. TB, fungal or viral infections.
Precautions
Ophthalmic: Glaucoma; monitor intraocular pressure regularly if used for >10 days.
Pregnancy-Lactation
Interactions
Additive toxicity with neurotoxic, ototoxic or nephrotoxic drugs. Increased neuromuscular blockade and possibly respiratory depression with neuromuscular blocking agents if significant amounts of neomycin absorbed significantly.
Adverse Effects
Side effects of Hydrocortisone + Neomycin Sulphate + Polymixin B Eye prep :
Ophthalmic: Irritation, increased intraocular pressure, glaucoma, posterior subcapsular cataract formation, delayed wound healing, secondary infections.
Mechanism of Action
Neomycin, an aminoglycoside with spectrum similar to gentamicin, binds to the 30S subunits of the bacterial ribosome, inhibiting protein synthesis and thereby disrupting DNA synthesis. It is active against many Gram-negative aerobes and some strains of staphylococci. Polymyxin B disrupts bacterial cell membrane and has bactericidal action against most Gram-negative bacilli. It is inactive against Gram-positive bacteria, obligate anaerobes and Neisseria spp. When used together, they are active against Staphylococcus aureus, Escherichia coli, Haemophilus influenzae, Klebsiella-Enterobacter species, Neisseria species, and Pseudomonas aeruginosa but have inadequate coverage against Serratia marcescens and streptococci, including Streptococcus pneumoniae. Hydrocortisone, a corticosteroid with mainly glucocorticoid activity, suppresses inflammatory response.