Iloperidone
Indications
Iloperidone is used for:
Schizophrenia
Adult Dose
Schizophrenia
Day 1: 1 mg PO q12hr; increase qDay to effective dose of 6-12 mg PO q12hr
Day 2: 2 mg PO q12hr, THEN increase qDay by 2 mg/day to effective dose of 6-12 mg PO q12hr; not to exceed 24 mg/day
Must gradually increase dose to avoid orthostatic hypotension
Hepatic impairment
Mild: No dosage adjustment required
Moderate: Caution advised
Severe: Use not recommended
Child Dose
Safety and efficacy not established
Renal Dose
Renal impairment: Unlikely to have a significant impact since <1% of drug is excreted unchanged in urine
Administration
Contra Indications
Hypersensitivity.
Precautions
This drug is not approved for the treatment of patients with dementia-related psychosis.
Prolongs QT interval; caution with other drugs/conditions that increase QTc.
Not recommended in hepatic impairment.
Risk of neuroleptic malignant syndrome and extrapyramidal symptoms.
May cause anticholinergic side effects (eg., confusion, agitation).
Blood dyscrasias (leukopenia, neutropenia, agranulocytosis) may occur.
Orthostatic hypotension may occur.
Lactation: not known if excreted in breast milk, do not nurse
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Iloperidone :
>10%
Dizziness (20%), Dry mouth (15%), Nausea (10%), Somnolence (10%), Tachycardia (12%)
1-10% (selected)
Diarrhea, Ejaculation failure, Myalgia, Nasal congestion, Orthostatic hypotension, Palpitations, Urinary incontinence, Weight gain
Frequency Not Defined (selected)
Priapism
Mechanism of Action
May act by antagonizing a combination of dopamine type 2 (D2) and serotonin type 2 (5-HT2) receptors.
Alpha blocker.